Beagle is a Cray XE6 supercomputer dedicated to biomedical research, funded by the NIH, owned by the University of Chicago Biological Sciences Division, and operated by the Computation Institute. With 24,000 compute cores, 2 petabytes of storage, and a peak speed of 212 teraflops (212 trillion calculations per second), Beagle allows researchers in biology and medicine to dramatically scale up data analysis, modeling, and simulation tasks. Current projects conducted on Beagle span the breadth of biomedical research at the University of Chicago, including genomics, neuroscience, medical imaging, molecular biology, drug discovery, traumatic injury, and more.