Edwin M. Munro



My lab seeks to understand how the dynamic behaviors of embryonic cells and tissues emerge through the interplay between biochemical regulation, cytoskeletal dynamics and cytomechanics. We are particularly interested in how embryonic cells organize, modulate and deploy actomyosin contractility do different jobs in different contexts. We focus in two main areas: cell polarization and asymmetric cell division in the nematode worm C. elegans, and the dynamics of cellular morphogenesis in ascidians. We work at the interface between experimental and computational biology, combining quantitative microscopy, molecular genetic, pharmacological and physical manipulations, and detailed computer simulations that predict cell and tissue level dynamics from known or hypothesized molecular interactions